毕洪论 师资博士后
E-mail：honglunbi@henu.edu.cn
学科：昆虫生理生化；昆虫分子生物学
教育及工作经历
2020.7- 至今：河南大学，师资博士后，研究方向：昆虫性别决定机制研究
2016.9-2020.6：华东师范大学生命科学学院，动物学专业，昆虫生理生态学方向，博士
2013.9-2016.7：福建农林大学生命科学学院，生物化学与分子生物学专业，硕士
2009.9-2013.7：商丘师范学院生命科学学院，生物科学专业，学士
研究领域
1. 基于基因编辑技术的昆虫遗传调控研究；
2. 昆虫性别决定机制研究。
承担科研项目
1. 国家自然科学基金-青年科学基金，保幼激素协同性别决定基因Doublesex调控飞蝗体色二态性的分子机制（32202314），2023.01-2025.12，30万元，在研，主持
2. 河南省科技攻关项目，基于基因编辑和性别决定的亚洲玉米螟生物防治技术的研究及应用（222102110108），2022.01-2023.12，10万元，在研，主持
代表性论文(*通讯作者)
1. Bi Honglun, Li Xiaowei, Xu Xia, Wang Yaohui, Zhou Shutang*, Huang Yongping*. 2022. Masculinizer and Doublesex as key factors regulate sexual dimorphism in Ostrinia furnacalis. Cells, 11(14), 2161.
2. Bi Honglun, Xu Xia, Li Xiaowei, Wang Yaohui, Zhou Shutang*, Huang Yongping*. 2022. CRISPR/Cas9-mediated Serine protease 2 disruption induces male sterility in Spodoptera litura. Frontiers in Physiology, 13, 931824.
3. Bi Honglun, Merchant Austin, Gu Junwen, Li Xiaowei, Zhou Xuguo, Zhang Qi*. 2022. CRISPR/Cas9-Mediated Mutagenesis of Abdominal-A and Ultrabithorax in the Asian Corn Borer, Ostrinia furnacalis. Insects, 13(4), 384.
4. Xu Xia#, Bi Honglun#, Wang Yaohui, Li Xiaowei, Xu Jun, Liu Zulian, He Lin*, Li Kai*, Huang Yongping*. 2020. Disruption of the ovarian serine protease (Osp) gene causes female sterility in Bombyx mori and Spodoptera litura. Pest Management Science. 76:1245-1255.
5. Bi Honglun, Xu Jun, He Lin, Zhang Yong, Li Kai*, Huang Yongping*. 2019. CRISPR/Cas9-mediated ebony knockout results in puparium melanism in Spodoptera litura. Insect Science. 26:1011-1019. (Cover story)
6. Bi Honglun, Xu Xia, Li Xiaowei, Zhang Yong, Huang Yongping, Li Kai*, Xu Jun*. 2019. CRISPR Disruption of BmOvo Resulted in the Failure of Emergence and Affected the Wing and Gonad Development in the Silkworm Bombyx mori. Insects. 10:254.
7. Bi Honglun, Xu Jun, Tan Anjiang, Huang Yongping*. 2016. CRISPR/Cas9‐mediated targeted gene mutagenesis in Spodoptera litura. Insect Science. 23:469-477.
8. Chen Shuqing#, Hou Chengxiang#, Bi Honglun, Wang Yueqiang, Xu Jun, Li Muwang, James Anthony A, Huang Yongping*, Tan Anjiang*. 2017. Transgenic Clustered Regularly Interspaced Short Palindromic Repeat/Cas9-Mediated Viral Gene Targeting for Antiviral Therapy of Bombyx mori Nucleopolyhedrovirus. Journal of Virology. 91(8):e02465-16.
9. You Lang, Bi Honglun, Wang Yaohui, Li Xiaowei, Chen Xi’en, Li Zhiqian*. 2019. CRISPR/Cas9‐based mutation reveals Argonaute 1 is essential for pigmentation in Ostrinia furnacalis.Insect Science. 26:1020-1028.
10. Xu Xia, Bi Honglun, Zhang Zhongjie, Yang Yang, Li Kai, Huang Yongping, Zhang Yong*, He Lin*. 2018. BmHpo mutation induces smaller body size and late stage larval lethality in the silkworm, Bombyx mori. Insect Science. 25:1006-1016.
11. Xu Jun, Bi Honglun, Chen Rongmei, Aslam Abu F M, Li Zhiqian, Ling Lin, Zeng Baosheng, Huang Yongping*, Tan Anjiang*. 2015. Transgenic characterization of two testis‐specific promoters in the silkworm, Bombyx mori. Insect Molecular Biology. 24:183-190.
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