吴忠霞




    忠霞  博士,副教授,硕士生导师。

    E-mail: wuz@vip.henu.edu.cn; wuzhongxia881120@126.com

    研究领域:昆虫发育与生殖;昆虫生理生化


    教育经历

    2021至今    河南大学,副教授。

    2016-2020 河南大学,讲师。研究方向:昆虫生殖发育

    2010-2016 中国科学技术大学,博士。研究内容:飞蝗生殖发育的内分泌调控

    2006-2010 安徽师范大学,本科。专业:生物科学


    研究领域

    1. 从保幼激素信号通路关键分子的翻译后修饰调控出发,深入解析保幼激素信号转导的分子机制。

    2. 探索与保幼激素信号协同调控昆虫生殖发育的分子通路。

    3. 解析成虫脂肪体细胞增殖方式和细胞命运决定,阐明脂肪体重建的分子机制。

    4. 阐明飞蝗多次产卵的调控机制。


    承担科研项目
    1. 国家自然科学基金面上
    项目,32172389,保幼激素和胰岛素通过Medea调控飞蝗成虫脂肪体重塑的分子机制,2022/01-2025/12, 55万元,在研,主持

    2. 国家自然科学基金青年项目,31702062,保幼激素触发Kr-h1磷酸化而激活转录调控功能的分子机制,2018/01-2020/12,25万元,结题,主持

    3. 河南省优秀青年基金,农作物害虫大量繁殖的内分泌调控机制,2023/01-2025/12,25万元,在研,主持



    代表性论文(*通讯作者)

    1. Zeng B, Zhao W, Ma J, Wu Z*. 2022. Replication protein A is required for juvenile hormone-dependent vitellogenesis and oocyte maturation in locusts. J Insect Physiol. 136:104345.

    2. Wu Z., Yang L., Li H., Zhou S*., 2021. Krüppel-homolog 1 exerts anti-metamorphic and vitellogenic functions in insects via phosphorylation-mediated recruitment of specific cofactors. BMC Biol. Accepted.

    3. Wu, Z., Yang L., He Q., Zhou S*., 2021. Regulatory mechanisms of vitellogenesis in insects. Front Cell Dev Biol. 28(8): 593613.

    4. Wu Z., He Q., Zeng B., Zhou H., Zhou S., 2020. Juvenile hormone acts through FoxO to promote Cdc2 and Orc5 transcription for polyploidy-dependent vitellogenesis. Development 147(18):dev188813.

    5. Guo W, Wu Z#, Yang L, Cai Z, Zhao L, Zhou S*. 2019. Juvenile hormone-dependent Kazal-type serine protease inhibitor Greglin safeguards insect vitellogenesis and egg production. FASEB J. 33(1): 917-927.(#co-first author)

    6. Wu Z, Guo W, Yang L, He Q, Zhou S*. 2018. Juvenile hormone promotes locust fat body cell polyploidization and vitellogenesis by activating the transcription of Cdk6 and E2f1. Insect Biochem Mol Biol. 102: 1-10.

    7. Wu Z, Guo W,Xie Y, Zhou S*. 2016. Juvenile hormone activates the transcription of Cell-division-cycle 6 (Cdc6) for polyploidy-dependent insect vitellogenesis and oogenesis. J Biol Chem. 291(10): 5418-27.

    8. Guo W#, Wu Z#, Song J. Jiang F, Deng S, Walker VK, Zhou S*. 2014. Juvenile hormone-receptor complex acts on Mcm4 and Mcm7 to promote polyploidy and vitellogenesis in the migratory locust. PLoS Genetics. 10(10): e1004702. (#co-first author)

    9. Song J, Wu Z, Wang Z, Deng S, Zhou S*. 2014. Krüppel-homolog 1 mediates juvenile hormone action to promote vitellogenesis and oocyte maturation in the migratory locust. Insect Biochem Mol Biol. 52: 94-101.

    10.  Ren D, Cai Z, Song J, Wu Z, Zhou S*. 2014. dsRNA uptake and persistence account for tissue-dependent susceptibility to RNA interference in the migratory locust, Locusta migratoria. Insect Mol Biol. 23(2): 175–184.